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Exenatide enhances kaliuresis under conditions of hyperkalemia.

Bull Exp Biol Med · 2011

Last updated 2026-05-28

In rats, the drug exenatide increased potassium excretion in urine from 7 to 16 micromoles per hour when potassium levels were normal. Under conditions of high potassium (hyperkalemia), exenatide doubled potassium excretion to 97 micromoles per hour compared to 47 micromoles per hour without the drug.

AI summary of the abstract below.

JournalBull Exp Biol Med, 2011
Citations3
Relative citation ratio0.07
NIH percentile6
Molecules exenatide

Abstract

Experiments on Wistar rats showed that exenatide (0.015-0.5 nmol per 100 g body weight) somewhat increased renal excretion of potassium from 7±1 to 16±1 μmol/h/100 g body weight (p<0.05) in animals with normal serum concentration of glucose (4.6±0.4 mM) and potassium (4.3±0.1 mM). Exenatide dramatically enhanced excretion of potassium under conditions of hyperkalemia (11.4±0.4 mM) produced by intraperitoneal injection of 1.25% KCl solution (5 ml per 100 g body weight). During the first postinjection hour, potassium excretion increased 2-fold and attained 97±11 μmol/h/100 g body weight in comparison with potassium load alone (47±9 μmol/h/100 g body weight, p<0.05). The data attest to a possible role of peptide regulators in normalization of potassium balance via renal mechanisms.

Verbatim abstract via PubMed 22808453 ↗

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