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Effects of exenatide combined with lifestyle modification in patients with type 2 diabetes.
Am J Med · 2010
Last updated 2026-05-28In a 24-week study of 194 people with type 2 diabetes, those who took exenatide (5–10 micrograms twice daily) alongside a lifestyle program lost an average of 6.16 kg, compared to 3.97 kg for those on placebo. The exenatide group also showed greater improvements in blood sugar control (a 1.21% vs 0.73% drop in hemoglobin A1c) and reductions in blood pressure. However, nausea was more common with exenatide (44.8% vs 19.4%). No differences were found in side effects leading to withdrawal or hypoglycemia rates.
AI summary of the abstract below.
| Journal | Am J Med, 2010 |
|---|---|
| Citations | 85 |
| Relative citation ratio | 2.31 |
| NIH percentile | 78 |
| Molecules | exenatide |
| Conditions studied | Type 2 Diabetes |
Abstract
OBJECTIVE: To determine the effect of a lifestyle modification program plus exenatide versus lifestyle modification program plus placebo on weight loss in overweight or obese participants with type 2 diabetes treated with metformin and/or sulfonylurea.
METHODS: In this 24-week, multicenter, randomized, double-blind, placebo-controlled study, 194 patients participated in a lifestyle modification program, consisting of goals of 600 kcal/day deficit and physical activity of at least 2.5 hours/week. Participants were randomized to 5 microg exenatide twice daily injection + lifestyle modification program (n = 96) or placebo + lifestyle modification program (n = 98), and after 4 weeks increased their exenatide dose to 10 microg twice daily or volume equivalent of placebo.
RESULTS: Baseline characteristics: (mean +/- standard deviation) age, 54.8 +/- 9.5 years; weight, 95.5 +/- 16.0 kg; hemoglobin A(1c), 7.6 +/- 0.8%. At 24 weeks (least squares mean +/- standard error), treatments showed similar decreases in caloric intake (-378 +/- 58 vs -295 +/- 58 kcal/day, exenatide + lifestyle modification program vs placebo + lifestyle modification program, P = .27) and increases in exercise-derived energy expenditure. Exenatide + lifestyle modification program showed greater change in weight (-6.16 +/- 0.54 kg vs -3.97 +/- 0.52 kg, P = .003), hemoglobin A(1c) (-1.21 +/- 0.09% vs -0.73 +/- 0.09%, P <.0001), systolic (-9.44 +/- 1.40 vs -1.97 +/- 1.40 mm Hg, P <.001) and diastolic blood pressure (-2.22 +/- 1.00 vs 0.47 +/- 0.99 mm Hg, P = .04). Nausea was reported more for exenatide + lifestyle modification program than placebo + lifestyle modification program (44.8% vs 19.4%, respectively, P <.001), with no difference in withdrawal rates due to adverse events (4.2% vs 5.1%, respectively, P = 1.0) or rates of hypoglycemia.
CONCLUSIONS: When combined with lifestyle modification, exenatide treatment led to significant weight loss, improved glycemic control, and decreased blood pressure compared with lifestyle modification alone in overweight or obese participants with type 2 diabetes on metformin and/or sulfonylurea treatment.
Verbatim abstract via PubMed 20399326 ↗
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