GLPwatch
Rybelsus for Anxiety
semaglutide · Investigational / off-label
Last updated 2026-05-28 15:46 UTCRybelsus (semaglutide) is not FDA-approved for treating anxiety, and any use for this condition is off-label or investigational. Research includes mixed findings, such as animal studies suggesting potential anxiolytic effects and human data primarily focused on adverse event reporting or psychiatric safety in other contexts.
AI summary of the sources below.
| Drug | Rybelsus (semaglutide) |
|---|---|
| Condition | Anxiety |
| Approval status | Investigational / off-label |
| Research papers | 13 |
Rybelsus is not FDA-approved for anxiety; the research below reflects investigational or off-label study only.
Research on semaglutide for anxiety (13)
- Association of semaglutide with risk of suicidal ideation in a real-world cohort.
- Disproportionality Analysis From World Health Organization Data on Semaglutide, Liraglutide, and Suicidality.
- Psychiatric Safety of Semaglutide for Weight Management in People Without Known Major Psychopathology: Post Hoc Analysis of the STEP 1, 2, 3, and 5 Trials.
- Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: a pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database.
- Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.
- Semaglutide in Psychiatry-Opportunities and Challenges.
- Psychiatric and psychological adverse effects associated with dulaglutide, semaglutide, and liraglutide: A vigibase study.
- Beyond Diabetes: Semaglutide's Role in Modulating Mood Disorders through Neuroinflammation Pathways.
- Semaglutide and risk of suicidal ideations.
- Semaglutide: A New Medical Swiss Army Knife?
- Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide.
- [Effects of semaglutide on mental health].
- Semaglutide Linked With Lower Risk of Suicidal Thoughts.