Ozempic vs Zepbound
Drug comparison
Last updated 2026-05-28 15:46 UTCOzempic (semaglutide by Novo Nordisk) is a once-weekly injection approved for type 2 diabetes, reducing cardiovascular risk, and chronic kidney disease. Zepbound (tirzepatide by Eli Lilly) is also a once-weekly injection but is approved for obesity and obstructive sleep apnea. The main difference is their active ingredients—semaglutide vs. tirzepatide—and their approved uses, with Ozempic targeting diabetes-related conditions and Zepbound focusing on weight management and sleep apnea.
AI summary of the sources below.
| Ozempic | Zepbound | |
|---|---|---|
| Active ingredient | semaglutide | tirzepatide |
| Manufacturer | novo-nordisk | eli-lilly |
| Route | subcutaneous injection | subcutaneous injection |
| FDA-approved for | type 2 diabetes, cardiovascular risk reduction, chronic kidney disease | obesity, obstructive sleep apnea |
| Label updated | 2026-01-30 | 2026-04-22 |