GLPwatch

Ozempic vs Zepbound

Drug comparison

Last updated 2026-05-28 15:46 UTC

Ozempic (semaglutide by Novo Nordisk) is a once-weekly injection approved for type 2 diabetes, reducing cardiovascular risk, and chronic kidney disease. Zepbound (tirzepatide by Eli Lilly) is also a once-weekly injection but is approved for obesity and obstructive sleep apnea. The main difference is their active ingredients—semaglutide vs. tirzepatide—and their approved uses, with Ozempic targeting diabetes-related conditions and Zepbound focusing on weight management and sleep apnea.

AI summary of the sources below.

Ozempic Zepbound
Active ingredientsemaglutidetirzepatide
Manufacturernovo-nordiskeli-lilly
Routesubcutaneous injectionsubcutaneous injection
FDA-approved fortype 2 diabetes, cardiovascular risk reduction, chronic kidney diseaseobesity, obstructive sleep apnea
Label updated2026-01-302026-04-22

Compare full details on the Ozempic and Zepbound pages.