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Mounjaro vs Rybelsus

Drug comparison

Last updated 2026-05-28 15:46 UTC

Mounjaro is a once-weekly injection containing tirzepatide, made by Eli Lilly, and is FDA-approved to treat type 2 diabetes. Rybelsus is a daily oral pill containing semaglutide, made by Novo Nordisk, and is also FDA-approved to treat type 2 diabetes. The main differences are that Mounjaro is injected and Rybelsus is taken by mouth.

AI summary of the sources below.

Mounjaro Rybelsus
Active ingredienttirzepatidesemaglutide
Manufacturereli-lillynovo-nordisk
Routesubcutaneous injectionoral
FDA-approved fortype 2 diabetestype 2 diabetes
Label updated2026-04-222026-01-30

Compare full details on the Mounjaro and Rybelsus pages.