GLPwatch
Byetta vs Rybelsus
Drug comparison
Last updated 2026-05-28 15:46 UTCByetta is an injectable diabetes medication containing exenatide, made by AstraZeneca, while Rybelsus is an oral diabetes medication containing semaglutide, made by Novo Nordisk. Both are FDA-approved to treat type 2 diabetes, but Byetta is taken as a shot under the skin, whereas Rybelsus is taken as a pill by mouth.
AI summary of the sources below.
| Byetta | Rybelsus | |
|---|---|---|
| Active ingredient | exenatide | semaglutide |
| Manufacturer | astrazeneca | novo-nordisk |
| Route | subcutaneous injection | oral |
| FDA-approved for | type 2 diabetes | type 2 diabetes |
| Label updated | 2025-09-02 | 2026-01-30 |