Bydureon vs Rybelsus
Drug comparison
Last updated 2026-05-28 15:46 UTCBydureon (exenatide by AstraZeneca) is a once-weekly injection for type 2 diabetes, while Rybelsus (semaglutide by Novo Nordisk) is a daily pill for the same condition. The main differences are how they’re taken—Bydureon is a shot under the skin, and Rybelsus is a tablet swallowed by mouth—and their active ingredients, exenatide versus semaglutide.
AI summary of the sources below.
| Bydureon | Rybelsus | |
|---|---|---|
| Active ingredient | exenatide | semaglutide |
| Manufacturer | astrazeneca | novo-nordisk |
| Route | subcutaneous injection | oral |
| FDA-approved for | type 2 diabetes | type 2 diabetes |
| Label updated | — | 2026-01-30 |